The Girgenti Lab @Yale Psychiatry
In the Girgenti Functional Neurogenomics lab, our goal is to elucidate the molecular neurobiology of PTSD and other psychiatric disorders using postmortem human brain and patient-derived cell lines to identify novel targets for drug discovery and development.
PTSD is a severe, debilitating, and prevalent disorder occurring in the aftermath of significant trauma exposure. The neurobiology of PTSD with regard to trauma-associated genetic, epigenetic, and transcriptional mechanisms is poorly understood and many critical questions remain. Recently, our group published the first large genomic study of the PTSD frontal cortex, one of the key components of the fear neural circuit, arguably among the best-understood circuits in neuroscience.